Kalanchoe daigremontiana: Functional Properties and Histopathological Effects on Wistar Rats under Hyperglycemia-inducing Diet

Abstract: Introduction: Diabetes is a worldwide pandemic disease with an expensive way of control. Locals around the world have been used botanical extracts to reduce effects this deadly improve quality life patients. Objectives: To evaluate crude ethnobotanical species K. daigremontiana on hyperglycemia rat model support its antidiabetic use in traditional medicine. Materials and Methods: Crude leaves extract were daily administered per os Wistar rats for six months. Hyperglycemic induction was rich-sucrose diets. Six animals group used: i) standard diet, ii) sucrose-rich iii) diet + (1 ml), iv) (2 ml) v) ml). All sacrificed liver prepared histopathological analysis. Powdered functionally characterized analyzed by Fourier Transform Infrared (FTIR) spectroscopy. Results: Treatment 2 ml caused least tissue damage, compared A high antioxidant activity (DPPH: 111.14 μM Trolox equivalents g-1 dry weight (DW); ABTS: 223.90 DW) observed. content 0.54 mg ascorbic acid DW, total phenol 17.45 gallic DW flavonoid 2.3 equivalent quercetin determined. No conclusive evidence molecules present obtained FTIR Conclusion: The dosages Kalanchoe reduces damage under sucrose conditions. Key words: Traditional medicine, Anti-hyperglycemic, Sucrose-rich daigremontiana, Phytotherapy.